Interrelation Between Protein Synthesis, Proteostasis and Life Span

Interrelation Between Protein Synthesis, Proteostasis and Life Span

The production of newly synthesized proteins is a key process of protein homeostasis that initiates the biosynthetic flux of proteins and thereby determines the composition, stability and functionality of the proteome. Protein synthesis is highly regulated on multiple levels to adapt the proteome to environmental and physiological challenges such as aging and proteotoxic conditions. Imbalances ...

Life Span and Disability

Psychiatric functioning and disability have historically been considered separate from the broader disability field and have been measured differently than other medical conditions. This paper provides an overview of the current concepts and international advances in the classification of psychiatric disability and explores the controversies and goals within the proposed systems. It highlights ...

Developmental regulation across the life span: toward a new synthesis.

How can individuals regulate their own development to live happy, healthy, and productive lives? Major theories of developmental regulation across the life span have been proposed (e.g., dual-process model of assimilation and accommodation; motivational theory of life-span development; model of selection, optimization, and compensation), but they have rarely been integrated. We provide an integ...

Interrelation Between Pinacidil and Intracellular ATP Concentrations

The patch-clamp technique was used to study the relation between pinacidil and intracellular ATP concentration ([ATP]i) on the activation of the outward K' current in guinea pig ventricular myocytes. Pinacidil shortened the action potential duration, exhibiting stronger effect at 2 mM [ATP]i than at 5 mM [ATP]i. Pinacidil at 5 ,M or higher concentrations activated the time-independent outward c...

Life Course, Environment Change, and Life Span